News Archive

Associations of Immunogenicity and Reactogenicity After Severe Acute Respiratory Syndrome Coronavirus 2 mRNA-1273 Vaccine in the COVE and TeenCOVE Trials

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Efficacy of a bivalent (D614 + B.1.351) SARS-CoV-2 recombinant protein vaccine with AS03 adjuvant in adults: a phase 3, parallel, randomised, modified double-blind, placebo-controlled trial

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Nasopharyngeal Viral Load Is the Major Driver of Incident Antibody Immune Response to SARS-CoV-2 Infection

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Safety and Immunogenicity of an Andes Virus DNA Vaccine by Needle-Free Injection: A Randomized, Controlled Phase 1 Study

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Maternal COVID-19 Vaccination and Prevention of Symptomatic Infection in Infants

Altered IgG4 antibody response to repeated mRNA versus recombinant protein SARS-CoV-2 vaccines

A Risk Profile Using Simple Hematologic Parameters to Assess Benefits From Baricitinib in Patients Hospitalized With COVID-19: A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-2

Immunomodulators for immunocompromised patients hospitalized for COVID-19: a meta-analysis of randomized controlled trials

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Modifiers of COVID-19 vaccine efficacy: Results from four COVID-19 prevention network efficacy trials

Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys

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Comparison of bivalent and monovalent SARS-CoV-2 variant vaccines: the phase 2 randomized open-label COVAIL trial

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Efficacy of a monovalent (D614) SARS-CoV-2 recombinant protein vaccine with AS03 adjuvant in adults: a phase 3, multi-country study

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Examining protective effects of SARS-CoV-2 neutralizing antibodies after vaccination or monoclonal antibody administration

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Evaluating Demographic Representation in Clinical Trials: Use of the Adaptive Coronavirus Disease 2019 Treatment Trial (ACTT) as a Test Case

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Kinetics of the Antibody Response to Symptomatic SARS-CoV-2 Infection in Vaccinated and Unvaccinated Individuals in the Blinded Phase of the mRNA-1273 COVID-19 Vaccine Efficacy Trial

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A Prospective Study of Key Correlates for Household Transmission of Severe Acute Respiratory Syndrome Coronavirus 2

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Viral Resistance Analyses From the Remdesivir Phase 3 Adaptive COVID-19 Treatment Trial-1 (ACTT-1)

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Immunogenicity of NVX-CoV2373 heterologous boost against SARS-CoV-2 variants.

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Innate immunity and interferon in SARS-CoV-2 infection outcome

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Retrospective, Observational Studies for Estimating Vaccine Effects on the Secondary Attack Rate of SARS-CoV-2

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NVX-CoV2373 vaccine efficacy against hospitalization: A post hoc analysis of the PREVENT-19 phase 3, randomized, placebo-controlled trial

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Immunogenicity of NVX-CoV2373 in PREVENT-19: A Phase 3, Randomized, Placebo-Controlled Trial in Adults in the United States and Mexico

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Comparing antibody assays as correlates of protection against COVID-19 in the COVE mRNA-1273 vaccine efficacy trial

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Safety, Immunogenicity, and Efficacy of the NVX-CoV2373 COVID-19 Vaccine in Adolescents

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Immunogenicity of the BA.1 and BA.4/BA.5 Severe Acute Respiratory Syndrome Coronavirus 2 Bivalent Boosts: Preliminary Results From the COVAIL Randomized Clinical Trial

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Meningococcal ACWYX Conjugate Vaccine in 2-to-29-Year-Olds in Mali and Gambia. Fadima Haidara et al

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Rapid Development of an Integrated Network Infrastructure to Conduct Phase 3 COVID-19 Vaccine Trials

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Immune correlates analysis of a phase 3 trial of the AZD1222 (ChAdOx1 nCoV-19) vaccine

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Efficacy of a bivalent (D614 + B.1.351) SARS-CoV-2 Protein Vaccine

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Robust humoral and cellular recall responses to AZD1222 attenuate breakthrough SARS-CoV-2 infection compared to unvaccinated

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Immune correlates analysis of the PREVENT-19 COVID-19 vaccine efficacy clinical trial

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Temporal Improvements in COVID-19 Outcomes for Hospitalized Adults: A Post Hoc Observational Study of Remdesivir Group Participants in the Adaptive COVID-19 Treatment Trial

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Humoral Immunogenicity of the mRNA-1273 Vaccine in the Phase 3 Coronavirus Efficacy (COVE) Trial

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Evaluation of mRNA-1273 Vaccine in Children 6 Months to 5 Years of Age

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Efficacy and safety of a single dose of casirivimab and imdevimab for the prevention of COVID-19 over an 8-month period: a randomised, double-blind, placebo-controlled trial

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The COVID-19 Pandemic Unmasked the Challenges Faced by Early-Stage Faculty in Infectious Diseases: A Call to Action

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Antinucleocapsid Antibodies After SARS-CoV-2 Infection in the Blinded Phase of the Randomized, Placebo-Controlled mRNA-1273 COVID-19 Vaccine Efficacy Clinical Trial

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Safety, Immunogenicity and Efficacy of NVX-CoV2373 in Adolescents in PREVENT-19: A Randomized, Phase 3 Trial

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Durability of protection and immunogenicity of AZD1222 (ChAdOx1 nCoV-19) COVID-19 vaccine over 6 months

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Detection and Kinetics of Subgenomic Severe Acute Respiratory Syndrome Coronavirus 2 RNA Viral Load in Longitudinal Diagnostic RNA-Positive Samples

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Leveraging lessons learned from the COVID-19 pandemic for HIV

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Rapid decline in vaccine-boosted neutralizing antibodies against SARS-CoV-2 Omicron variant

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SARS-CoV-2 Variant Vaccine Boosters Trial: Preliminary Analyses

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Mapping SARS-CoV-2 antigenic relationships and serological responses

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Deconstructing the Treatment Effect of Remdesivir in the Adaptive Coronavirus Disease 2019 (COVID-19) Treatment Trial-1: Implications for Critical Care Resource Utilization

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Protocol for a sequential, prospective meta-analysis to describe coronavirus disease 2019 (COVID-19) in the pregnancy and postpartum periods

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COVID-19 booster vaccination during pregnancy enhances maternal binding and neutralizing antibody responses and transplacental antibody transfer to the newborn

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Durability of Protection Against Symptomatic COVID-19 Among Participants of the mRNA-1273 SARS-CoV-2 Vaccine Trial

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Evaluation of mRNA-1273 Covid-19 Vaccine in Children 6 to 11 Years of Age

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Serum levels of anti-PF4 IgG after AZD1222 (ChAdOx1 nCoV-19) vaccination

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Unraveling the Treatment Effect of Baricitinib on Clinical Progression and Resource Utilization in Hospitalized COVID-19 Patients: Secondary Analysis of the Adaptive COVID-19 Treatment Randomized Trial-2

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Effect of Subcutaneous Casirivimab and Imdevimab Antibody Combination vs Placebo on Development of Symptomatic COVID-19 in Early Asymptomatic SARS-CoV-2 Infection: A Randomized Clinical Trial

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Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial

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A Novel Recombinant Influenza Virus Neuraminidase Vaccine Candidate Stabilized by a Measles Virus Phosphoprotein Tetramerization Domain Provides Robust Protection from Virus Challenge in the Mouse Model

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Heterologous SARS-CoV-2 Booster Vaccinations - Preliminary Report

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Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial

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Multi-site observational maternal and infant COVID-19 vaccine study (MOMI-vax): a study protocol

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Statement from NIH and BARDA on the Novavax COVID-19 Vaccine

July 20, 2022

Effect of Subcutaneous Casirivimab and Imdevimab Antibody Combination vs Placebo on Development of Symptomatic COVID-19 in Early Asymptomatic SARS-CoV-2 Infection

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Booster of mRNA-1273 Strengthens SARS-CoV-2 Omicron Neutralization

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Could widespread use of antiviral treatment curb the COVID-19 pandemic? A modeling study

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Safety and Immunogenicity of a Third Dose of SARS-CoV-2 mRNA Vaccine — An Interim Analysis

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Impact of preexisting anti-Ad26 humoral immunity on immunogenicity of the Ad26.COV2.S COVID-19 vaccine

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Calibration of Two Validated SARS-CoV-2 Pseudovirus Neutralization Assays for COVID-19 Vaccine Evaluation

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Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 Variants

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Trajectory of Viral RNA Load Among Persons With Incident SARS-CoV-2 G614 Infection (Wuhan Strain) in Association With COVID-19 Symptom Onset and Severity

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Preserved Omicron Spike specific antibody binding and Fc-recognition across COVID-19 vaccine platforms

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Remdesivir for the Prevention of Invasive Mechanical Ventilation or Death in Coronavirus Disease 2019 (COVID-19): A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data

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Omicron variant Spike-specific antibody binding and Fc activity are preserved in recipients of mRNA or inactivated COVID-19 vaccines

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Safety and Immunogenicity of a 100 μg mRNA-1273 Vaccine Booster for Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)

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Initial analysis of viral dynamics and circulating viral variants during the mRNA-1273 Phase 3 COVE trial

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Heterologous COVID-19 Booster Vaccinations

New England Journal of Medicine Quick Take video

Durability of mRNA-1273 vaccine-induced antibodies against SARS-CoV-2 variants

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A Deferred-Vaccination Design to Assess Durability of COVID-19 Vaccine Effect After the Placebo Group Is Vaccinated

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A 'Mix and Match' Approach to SARS-CoV- 2 Vaccination

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Efficacy and Safety of the MRNA-1273 SARS-CoV- 2 Vaccine

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Development of a Rapid Focus Reduction Neutralization Test Assay for Measuring SARS-CoV-2 Neutralizing Antibodies

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An mRNA Vaccine against SARS-CoV-2 - Preliminary Report

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Final Analysis of Efficacy and Safety of Single-Dose Ad26.COV2.S

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NIH begins clinical trial evaluating second COVID-19 booster shots in adults

March 31, 2022

SARS-CoV-2 Omicron Variant Neutralization after mRNA-1273 Booster Vaccination

March 17, 2022

mRNA-1273 Vaccine-elicited Neutralization of SARS-CoV-2 Omicron in Adolescents and Children

January 25, 2022

Efficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico

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Sanofi and GSK to seek regulatory authorization for COVID-19 vaccine

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Homologous and Heterologous Covid-19 Booster Vaccinations

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SARS-CoV-2 Omicron Neutralization After Heterologous Vaccine Boosting

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mRNA-1273 vaccine-induced antibodies maintain Fc effector functions across SARS-CoV-2 variants of concern

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Phase 3 Trial of mRNA-1273 during the Delta-Variant Surge

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Booster of mRNA-1273 Vaccine Reduces SARS-CoV-2 Omicron Escape from Neutralizing Antibodies

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Initial Analysis of Viral Dynamics and Circulating Viral Variants During the mRNA-1273 Phase 3 COVE Trial

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Clinical utility of Elecsys Anti-SARS-CoV-2 S assay in COVID-19 vaccination: An exploratory analysis of the mRNA-1273 phase 1 trial

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Efficacy of interferon beta-1a plus remdesivir compared with remdesivir alone in hospitalised adults with COVID-19: a double-bind, randomised, placebo-controlled, phase 3 trial

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The role of antiviral treatment in curbing the COVID-19 pandemic: a modeling study

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Covid-19 in the Phase 3 Trial of mRNA-1273 During the Delta-variant Surge

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Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against COVID-19

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Durability of mRNA-1273 vaccine–induced antibodies against SARS-CoV-2 variants

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Subcutaneous Interferon Does Not Improve Outcomes for Hospitalized Adults with COVID-19

October 18, 2021

Efficacy of the mRNA-1273 SARS-CoV-2 Vaccine at Completion of Blinded Phase

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SARS-CoV-2 Neutralization with BNT162b2 Vaccine Dose 3

September 15, 2021

Phase 3 Safety and Efficacy of AZD1222 (ChAdOx1 nCoV-19) Covid-19 Vaccine

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Low-dose mRNA-1273 COVID-19 vaccine generates durable memory enhanced by cross-reactive T cells

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Performance Analysis of the National Early Warning Score and Modified Early Warning Score in the Adaptive COVID-19 Treatment Trial Cohort

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Neutralizing Antibodies Against SARS-CoV-2 Variants After Infection and Vaccination

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Antibodies elicited by mRNA-1273 vaccination bind more broadly to the receptor binding domain than do those from SARS-CoV-2 infection

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Antibody Persistence through 6 Months after the Second Dose of mRNA-1273 Vaccine for COVID-19

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U.S. clinical trial results show Novavax vaccine is safe and prevents COVID-19

June 14, 2021

SARS-CoV-2 Serologic Assays in Control and Unknown Populations Demonstrate the Necessity of Virus Neutralization Testing

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SARS-CoV-2 Infects Human Pluripotent Stem Cell-Derived Cardiomyocytes, Impairing Electrical and Mechanical Function

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Bamlanivimab for Prevention of COVID-19

Editorial

Safety, Immunogenicity, and Efficacy of the BNT162b2 Covid-19 Vaccine in Adolescents

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Evaluation of Cellular and Serological Responses to Acute SARS-CoV-2 Infection Demonstrates the Functional Importance of the Receptor-Binding Domain

June 1, 2021

Effect of Bamlanivimab vs Placebo on Incidence of COVID-19 Among Residents and Staff of Skilled Nursing and Assisted Living Facilities: A Randomized Clinical Trial

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Clinical Trial Evaluating Mixed COVID-19 Vaccine Schedules Begins

June 1, 2021

NIH closes enrollment in trial comparing COVID-19 treatment regimens

April 15, 2021

The SARS-CoV-2 mRNA-1273 vaccine elicits more RBD-focused neutralization, but with broader antibody binding within the RBD

April 14, 2021

Infection- and vaccine-induced antibody binding and neutralization of the B.1.351 SARS-CoV-2 variant

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Antibody Persistence through 6 Months after the Second Dose of mRNA-1273 Vaccine for Covid-19

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Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19

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Reduced binding and neutralization of infection- and vaccine-induced antibodies to the B.1.351 (South African) SARS-CoV-2 variant

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COVID-19 and the Path to Immunity

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Accounting for informative sampling in estimation of associations between sexually transmitted infections and hormonal contraceptive methods

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Accounting for informative sampling in estimation of associations between sexually transmitted infections and hormonal contraceptive methods

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The SARS-CoV-2 mRNA-1273 vaccine elicits more RBD-focused neutralization, but with broader antibody binding within the RBD

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The need for inclusion of pregnant women in COVID-19 vaccine trials

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NIH Clinical Trial Evaluating Moderna COVID-19 Variant Vaccine Begins

March 31, 2021

Baricitinib Therapy in Covid-19 Pneumonia — An Unmet Need Fulfilled

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Statement from NIH and BARDA on the FDA Emergency Use Authorization of the Janssen COVID-19 Vaccine

February 27, 2021

Infection and mRNA-1273 vaccine antibodies neutralize SARS-CoV-2 UK variant

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Janssen Investigational COVID-19 Vaccine: Interim Analysis of Phase 3 Clinical Data Released

January 29, 2021

Regeneron Reports Positive Interim Data with REGEN-COV™ Antibody Cocktail used as Passive Vaccine to Prevent COVID-19

January 26, 2021

Analysis Demonstrates Effectiveness of LY-CoV555 Antibody in Preventing Symptomatic COVID-19

January 25, 2021

Capital of public health

January 22, 2021

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

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Ride Health and COVID-19 Prevention Trials Network (CoVPN) Partner to Provide Transportation for Vaccine Trial Participants

January 20, 2021

Gritstone Advances Second Generation COVID-19 Vaccine “CORAL” Program with Support from NIAID; Program has Potential to Protect Against Mutant Variants of SARS-CoV-2

January 19, 2021

Nanoparticles: The Next Generation of Vaccine Technology

January 19, 2021

Fenway Health deploys mobile health clinic to increase access to and representation in COVID-19 research

January 14, 2021

Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination

January 7, 2021

Peer-reviewed report on Moderna COVID-19 vaccine publishes

December 30, 2020

Phase 3 trial of Novavax investigational COVID-19 vaccine opens

December 28, 2020

Statement from NIH and BARDA on the FDA Emergency Use Authorization of the Moderna COVID-19 Vaccine

December 18, 2020

Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

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Baricitinib plus remdesivir shows promise for treating COVID-19

December 11, 2020

Fourth iteration of COVID-19 treatment trial underway

November 25, 2020

Promising Interim Results from Clinical Trial of NIH-Moderna COVID-19 Vaccine

November 16, 2020

Development of a Rapid Focus Reduction Neutralization Test Assay for Measuring SARS‐CoV‐2 Neutralizing Antibodies

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Vaccine optimization for COVID-19: who to vaccinate first?

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A Geroscience Approach to Preventing Pathologic Consequences of COVID-19

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Rapid generation of neutralizing antibody responses in COVID-19 patients

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Warp Speed chief visits IDCRC & VTEU, urges participation in COVID vaccine trials

November 13

Fauci, Neuzil Address UAB at COVID-19 Research Symposium

October 28, 2020

NIH Director's Blog: "COVID-19 Vaccine Appears Well-Tolerated and Effective in Developing Antibodies in Small Study of Older Adults"

October 13, 2020

Investigational COVID-19 Vaccine Well-Tolerated and Generates Immune Response in Older Adults

September 29, 2020

NIH expands clinical trials to test convalescent plasma against COVID-19

September 22, 2020

Remdesivir for the Treatment of Covid-19 — Final Report

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Warp Speed for COVID-19 Vaccines: Why are Children Stuck in Neutral?

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Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

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Investigational COVID-19 Vaccine Well-Tolerated and Generates Immune Response in Older Adults

September 29, 2020

Fourth Large-Scale COVID-19 Vaccine Trial Begins in the United States

September 23, 2020

NIH Expands Clinical Trials to Test Convalescent Plasma Against COVID-19

September 22, 2020

Eli Lilly and Company: Baricitinib in Combination with Remdesivir Reduces Time to Recovery in Hospitalized Patients with COVID-19 in NIAID-Sponsored ACTT-2 Trial

September 14, 2020

Remdesivir for the Treatment of Covid-19 — Preliminary Report

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An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

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COVID-19 Prevention Network Launches Two Research Studies Evaluating Monoclonal Antibodies

August 10, 2020

NIH Clinical Trial Testing Remdesivir Plus Interferon Beta-1a for COVID-19 Treatment Begins

August 5, 2020

Phase 3 Clinical Trial of Investigational Vaccine for COVID-19 Begins

July 27, 2020