News Archive

Please include the following citation in any publications resulting from direct or indirect IDCRC support: "Supported by the Infectious Diseases Clinical Research Consortium through the National Institute for Allergy and Infectious Diseases of the National Institutes of Health, under award number UM1AI148684. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health."

Meningococcal ACWYX Conjugate Vaccine in 2-to-29-Year-Olds in Mali and Gambia. Fadima Haidara et al

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Rapid Development of an Integrated Network Infrastructure to Conduct Phase 3 COVID-19 Vaccine Trials

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Immune correlates analysis of a phase 3 trial of the AZD1222 (ChAdOx1 nCoV-19) vaccine

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Efficacy of a bivalent (D614 + B.1.351) SARS-CoV-2 Protein Vaccine

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AZD1222-induced nasal antibody responses are shaped by prior SARS-CoV-2 infection and correlate with virologic outcomes in breakthrough infectioN

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Robust humoral and cellular recall responses to AZD1222 attenuate breakthrough SARS-CoV-2 infection compared to unvaccinated

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Immune correlates analysis of the PREVENT-19 COVID-19 vaccine efficacy clinical trial

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Temporal Improvements in COVID-19 Outcomes for Hospitalized Adults: A Post Hoc Observational Study of Remdesivir Group Participants in the Adaptive COVID-19 Treatment Trial

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Humoral Immunogenicity of the mRNA-1273 Vaccine in the Phase 3 Coronavirus Efficacy (COVE) Trial

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Evaluation of mRNA-1273 Vaccine in Children 6 Months to 5 Years of Age

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Efficacy and safety of a single dose of casirivimab and imdevimab for the prevention of COVID-19 over an 8-month period: a randomised, double-blind, placebo-controlled trial

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The COVID-19 Pandemic Unmasked the Challenges Faced by Early-Stage Faculty in Infectious Diseases: A Call to Action

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Antinucleocapsid Antibodies After SARS-CoV-2 Infection in the Blinded Phase of the Randomized, Placebo-Controlled mRNA-1273 COVID-19 Vaccine Efficacy Clinical Trial

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Safety, Immunogenicity and Efficacy of NVX-CoV2373 in Adolescents in PREVENT-19: A Randomized, Phase 3 Trial

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Durability of protection and immunogenicity of AZD1222 (ChAdOx1 nCoV-19) COVID-19 vaccine over 6 months

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Detection and Kinetics of Subgenomic Severe Acute Respiratory Syndrome Coronavirus 2 RNA Viral Load in Longitudinal Diagnostic RNA-Positive Samples

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Leveraging lessons learned from the COVID-19 pandemic for HIV

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Rapid decline in vaccine-boosted neutralizing antibodies against SARS-CoV-2 Omicron variant

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SARS-CoV-2 Variant Vaccine Boosters Trial: Preliminary Analyses

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Mapping SARS-CoV-2 antigenic relationships and serological responses

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Deconstructing the Treatment Effect of Remdesivir in the Adaptive Coronavirus Disease 2019 (COVID-19) Treatment Trial-1: Implications for Critical Care Resource Utilization

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Protocol for a sequential, prospective meta-analysis to describe coronavirus disease 2019 (COVID-19) in the pregnancy and postpartum periods

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COVID-19 booster vaccination during pregnancy enhances maternal binding and neutralizing antibody responses and transplacental antibody transfer to the newborn

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Durability of Protection Against Symptomatic COVID-19 Among Participants of the mRNA-1273 SARS-CoV-2 Vaccine Trial

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Evaluation of mRNA-1273 Covid-19 Vaccine in Children 6 to 11 Years of Age

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Serum levels of anti-PF4 IgG after AZD1222 (ChAdOx1 nCoV-19) vaccination

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Unraveling the Treatment Effect of Baricitinib on Clinical Progression and Resource Utilization in Hospitalized COVID-19 Patients: Secondary Analysis of the Adaptive COVID-19 Treatment Randomized Trial-2

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Effect of Subcutaneous Casirivimab and Imdevimab Antibody Combination vs Placebo on Development of Symptomatic COVID-19 in Early Asymptomatic SARS-CoV-2 Infection: A Randomized Clinical Trial

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Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial

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A Novel Recombinant Influenza Virus Neuraminidase Vaccine Candidate Stabilized by a Measles Virus Phosphoprotein Tetramerization Domain Provides Robust Protection from Virus Challenge in the Mouse Model

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Heterologous SARS-CoV-2 Booster Vaccinations - Preliminary Report

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Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial

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Multi-site observational maternal and infant COVID-19 vaccine study (MOMI-vax): a study protocol

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Statement from NIH and BARDA on the Novavax COVID-19 Vaccine

July 20, 2022

Effect of Subcutaneous Casirivimab and Imdevimab Antibody Combination vs Placebo on Development of Symptomatic COVID-19 in Early Asymptomatic SARS-CoV-2 Infection

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Booster of mRNA-1273 Strengthens SARS-CoV-2 Omicron Neutralization

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Could widespread use of antiviral treatment curb the COVID-19 pandemic? A modeling study

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Safety and Immunogenicity of a Third Dose of SARS-CoV-2 mRNA Vaccine — An Interim Analysis

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Impact of preexisting anti-Ad26 humoral immunity on immunogenicity of the Ad26.COV2.S COVID-19 vaccine

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Calibration of Two Validated SARS-CoV-2 Pseudovirus Neutralization Assays for COVID-19 Vaccine Evaluation

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Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 Variants

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Trajectory of Viral RNA Load Among Persons With Incident SARS-CoV-2 G614 Infection (Wuhan Strain) in Association With COVID-19 Symptom Onset and Severity

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Preserved Omicron Spike specific antibody binding and Fc-recognition across COVID-19 vaccine platforms

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Remdesivir for the Prevention of Invasive Mechanical Ventilation or Death in Coronavirus Disease 2019 (COVID-19): A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data

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Omicron variant Spike-specific antibody binding and Fc activity are preserved in recipients of mRNA or inactivated COVID-19 vaccines

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Safety and Immunogenicity of a 100 μg mRNA-1273 Vaccine Booster for Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)

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Initial analysis of viral dynamics and circulating viral variants during the mRNA-1273 Phase 3 COVE trial

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Heterologous COVID-19 Booster Vaccinations

New England Journal of Medicine Quick Take video

Durability of mRNA-1273 vaccine-induced antibodies against SARS-CoV-2 variants

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A Deferred-Vaccination Design to Assess Durability of COVID-19 Vaccine Effect After the Placebo Group Is Vaccinated

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A 'Mix and Match' Approach to SARS-CoV- 2 Vaccination

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Efficacy and Safety of the MRNA-1273 SARS-CoV- 2 Vaccine

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Development of a Rapid Focus Reduction Neutralization Test Assay for Measuring SARS-CoV-2 Neutralizing Antibodies

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An mRNA Vaccine against SARS-CoV-2 - Preliminary Report

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Final Analysis of Efficacy and Safety of Single-Dose Ad26.COV2.S

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NIH begins clinical trial evaluating second COVID-19 booster shots in adults

March 31, 2022

SARS-CoV-2 Omicron Variant Neutralization after mRNA-1273 Booster Vaccination

March 17, 2022

mRNA-1273 Vaccine-elicited Neutralization of SARS-CoV-2 Omicron in Adolescents and Children

January 25, 2022

Efficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico

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Sanofi and GSK to seek regulatory authorization for COVID-19 vaccine

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Homologous and Heterologous Covid-19 Booster Vaccinations

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SARS-CoV-2 Omicron Neutralization After Heterologous Vaccine Boosting

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mRNA-1273 vaccine-induced antibodies maintain Fc effector functions across SARS-CoV-2 variants of concern

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Phase 3 Trial of mRNA-1273 during the Delta-Variant Surge

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Booster of mRNA-1273 Vaccine Reduces SARS-CoV-2 Omicron Escape from Neutralizing Antibodies

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Initial Analysis of Viral Dynamics and Circulating Viral Variants During the mRNA-1273 Phase 3 COVE Trial

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Clinical utility of Elecsys Anti-SARS-CoV-2 S assay in COVID-19 vaccination: An exploratory analysis of the mRNA-1273 phase 1 trial

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Efficacy of interferon beta-1a plus remdesivir compared with remdesivir alone in hospitalised adults with COVID-19: a double-bind, randomised, placebo-controlled, phase 3 trial

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The role of antiviral treatment in curbing the COVID-19 pandemic: a modeling study

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Covid-19 in the Phase 3 Trial of mRNA-1273 During the Delta-variant Surge

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Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against COVID-19

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Durability of mRNA-1273 vaccine–induced antibodies against SARS-CoV-2 variants

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Subcutaneous Interferon Does Not Improve Outcomes for Hospitalized Adults with COVID-19

October 18, 2021

Efficacy of the mRNA-1273 SARS-CoV-2 Vaccine at Completion of Blinded Phase

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SARS-CoV-2 Neutralization with BNT162b2 Vaccine Dose 3

September 15, 2021

Phase 3 Safety and Efficacy of AZD1222 (ChAdOx1 nCoV-19) Covid-19 Vaccine

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Low-dose mRNA-1273 COVID-19 vaccine generates durable memory enhanced by cross-reactive T cells

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Performance Analysis of the National Early Warning Score and Modified Early Warning Score in the Adaptive COVID-19 Treatment Trial Cohort

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Neutralizing Antibodies Against SARS-CoV-2 Variants After Infection and Vaccination

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Antibodies elicited by mRNA-1273 vaccination bind more broadly to the receptor binding domain than do those from SARS-CoV-2 infection

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Antibody Persistence through 6 Months after the Second Dose of mRNA-1273 Vaccine for COVID-19

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U.S. clinical trial results show Novavax vaccine is safe and prevents COVID-19

June 14, 2021

SARS-CoV-2 Serologic Assays in Control and Unknown Populations Demonstrate the Necessity of Virus Neutralization Testing

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SARS-CoV-2 Infects Human Pluripotent Stem Cell-Derived Cardiomyocytes, Impairing Electrical and Mechanical Function

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Bamlanivimab for Prevention of COVID-19

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Safety, Immunogenicity, and Efficacy of the BNT162b2 Covid-19 Vaccine in Adolescents

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Evaluation of Cellular and Serological Responses to Acute SARS-CoV-2 Infection Demonstrates the Functional Importance of the Receptor-Binding Domain

June 1, 2021

Effect of Bamlanivimab vs Placebo on Incidence of COVID-19 Among Residents and Staff of Skilled Nursing and Assisted Living Facilities: A Randomized Clinical Trial

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Clinical Trial Evaluating Mixed COVID-19 Vaccine Schedules Begins

June 1, 2021

NIH closes enrollment in trial comparing COVID-19 treatment regimens

April 15, 2021

The SARS-CoV-2 mRNA-1273 vaccine elicits more RBD-focused neutralization, but with broader antibody binding within the RBD

April 14, 2021

Infection- and vaccine-induced antibody binding and neutralization of the B.1.351 SARS-CoV-2 variant

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Antibody Persistence through 6 Months after the Second Dose of mRNA-1273 Vaccine for Covid-19

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Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19

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Reduced binding and neutralization of infection- and vaccine-induced antibodies to the B.1.351 (South African) SARS-CoV-2 variant

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COVID-19 and the Path to Immunity

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Accounting for informative sampling in estimation of associations between sexually transmitted infections and hormonal contraceptive methods

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Accounting for informative sampling in estimation of associations between sexually transmitted infections and hormonal contraceptive methods

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The SARS-CoV-2 mRNA-1273 vaccine elicits more RBD-focused neutralization, but with broader antibody binding within the RBD

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The need for inclusion of pregnant women in COVID-19 vaccine trials

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NIH Clinical Trial Evaluating Moderna COVID-19 Variant Vaccine Begins

March 31, 2021

Baricitinib Therapy in Covid-19 Pneumonia — An Unmet Need Fulfilled

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Statement from NIH and BARDA on the FDA Emergency Use Authorization of the Janssen COVID-19 Vaccine

February 27, 2021

Infection and mRNA-1273 vaccine antibodies neutralize SARS-CoV-2 UK variant

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Janssen Investigational COVID-19 Vaccine: Interim Analysis of Phase 3 Clinical Data Released

January 29, 2021

Regeneron Reports Positive Interim Data with REGEN-COV™ Antibody Cocktail used as Passive Vaccine to Prevent COVID-19

January 26, 2021

Analysis Demonstrates Effectiveness of LY-CoV555 Antibody in Preventing Symptomatic COVID-19

January 25, 2021

Capital of public health

January 22, 2021

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

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Ride Health and COVID-19 Prevention Trials Network (CoVPN) Partner to Provide Transportation for Vaccine Trial Participants

January 20, 2021

Gritstone Advances Second Generation COVID-19 Vaccine “CORAL” Program with Support from NIAID; Program has Potential to Protect Against Mutant Variants of SARS-CoV-2

January 19, 2021

Nanoparticles: The Next Generation of Vaccine Technology

January 19, 2021

Fenway Health deploys mobile health clinic to increase access to and representation in COVID-19 research

January 14, 2021

Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination

January 7, 2021

Peer-reviewed report on Moderna COVID-19 vaccine publishes

December 30, 2020

Phase 3 trial of Novavax investigational COVID-19 vaccine opens

December 28, 2020

Statement from NIH and BARDA on the FDA Emergency Use Authorization of the Moderna COVID-19 Vaccine

December 18, 2020

Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

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Baricitinib plus remdesivir shows promise for treating COVID-19

December 11, 2020

Fourth iteration of COVID-19 treatment trial underway

November 25, 2020

Promising Interim Results from Clinical Trial of NIH-Moderna COVID-19 Vaccine

November 16, 2020

Development of a Rapid Focus Reduction Neutralization Test Assay for Measuring SARS‐CoV‐2 Neutralizing Antibodies

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Vaccine optimization for COVID-19: who to vaccinate first?

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A Geroscience Approach to Preventing Pathologic Consequences of COVID-19

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Rapid generation of neutralizing antibody responses in COVID-19 patients

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Warp Speed chief visits IDCRC & VTEU, urges participation in COVID vaccine trials

November 13

Fauci, Neuzil Address UAB at COVID-19 Research Symposium

October 28, 2020

NIH Director's Blog: "COVID-19 Vaccine Appears Well-Tolerated and Effective in Developing Antibodies in Small Study of Older Adults"

October 13, 2020

Investigational COVID-19 Vaccine Well-Tolerated and Generates Immune Response in Older Adults

September 29, 2020

NIH expands clinical trials to test convalescent plasma against COVID-19

September 22, 2020

Remdesivir for the Treatment of Covid-19 — Final Report

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Warp Speed for COVID-19 Vaccines: Why are Children Stuck in Neutral?

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Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

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Investigational COVID-19 Vaccine Well-Tolerated and Generates Immune Response in Older Adults

September 29, 2020

Fourth Large-Scale COVID-19 Vaccine Trial Begins in the United States

September 23, 2020

NIH Expands Clinical Trials to Test Convalescent Plasma Against COVID-19

September 22, 2020

Eli Lilly and Company: Baricitinib in Combination with Remdesivir Reduces Time to Recovery in Hospitalized Patients with COVID-19 in NIAID-Sponsored ACTT-2 Trial

September 14, 2020

Remdesivir for the Treatment of Covid-19 — Preliminary Report

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An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

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COVID-19 Prevention Network Launches Two Research Studies Evaluating Monoclonal Antibodies

August 10, 2020

NIH Clinical Trial Testing Remdesivir Plus Interferon Beta-1a for COVID-19 Treatment Begins

August 5, 2020

Phase 3 Clinical Trial of Investigational Vaccine for COVID-19 Begins

July 27, 2020