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Infectious Diseases Clinical Research Consortium (IDCRC)

Infectious Diseases Clinical Research Consortium

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The Infectious Diseases Clinical Research Consortium (IDCRC) and Vaccine and Treatment Evaluation Units (VTEUs) work in tandem with the National Institute of Allergy and Infectious Diseases (NIAID) as a coordinated national and global network of scientific experts working to develop and test vaccines and other therapies to combat infectious diseases.

About

The IDCRC works through a flexible, sustaining structure to advance new countermeasures and approaches to product development, implement efficient clinical study/trial designs, and support exceptional career development and mentoring of future leaders in infectious diseases clinical research. The consortium's collective experience and access to diverse populations give it the ability to evaluate new vaccines and therapies for infectious diseases.

IDCRC Active & Completed Studies

Phase 3 Safety and Efficacy of AZD1222 (ChAdOx1 nCoV-19) COVID-19 Vaccine

IDCRC-supported results published in the New England Journal of Medicine

IDCRC News

COVID-19 Vaccine Appears Well-Tolerated and Effective in Developing Antibodies in Small Study of Older Adults

COVID-19 Prevention Network

The CoVPN was established by merging four existing NIAID-funded clinical trials networks: the HIV Vaccine Trials Network; the HIV Prevention Trials Network; the Infectious Diseases Clinical Research Consortium; and the AIDS Clinical Trials Group.

More about the CoVPN

COVID-19 Prevention Network launches two research studies evaluating monoclonal antibodies

IDCRC Sites Across the Nation

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News from VTEU Trials

COVID-19 in the Phase 3 Trial of mRNA-1273 During the Delta-variant Surge

This exploratory analysis evaluated the incidence and genetic sequences of COVID-19 cases in the ongoing COVE trial during the open-label phase, with a focus on July-August 2021, when delta-variants surged in the U.S.

Durability of mRNA-1273 vaccine–induced antibodies against SARS-CoV-2 variants

This team examined how viral variants, including the B.1.351 (Beta) and B.1.617.2 (Delta) variant, affected the immune response in a small number of individuals who received the Moderna mRNA-1273 vaccine.

SARS-CoV-2 Neutralization with BNT162b2 Vaccine Dose 3

NEJM editor correspondence

Efficacy of the mRNA-1273 SARS-CoV-2 Vaccine at Completion of Blinded Phase

Final analyses of efficacy and safety data from the blinded phase of the trial are reported.

IDCRC Leadership Group

IDCRC Vaccine & Treatment Evaluation Units (VTEUs)

IDCRC Concept Quick Stats

ICP Status

Approved: 26
Administratively Not Supported: 16
Revise & Resubmit: 6
Withdrawn: 7
Liaisons: 3
EWGs: 4
Not Approved: 28
EMT: 0
Other: 6

EWG Assignment

COVID: 71
Respiratory: 10
STI: 5
Malaria/Topical Diseases: 3
Enteric Infections: 2
Emerging Infections: 5

ECP

Protocol Development: 7
IDCRC Concept Study Underway: 2
Submitted to ACTIVE Mab Program per DMID: 1
Transitioned to CoVPN Trial: 1
Transitioned to ACTT 2: 1
Funded by NIAID via Other Mechanism: 1
Pending: 7
Not Approved: 0
In Process: 4
On Hold/Withdrawn: 5
Note: Protocols Transitioned to IDCRC for Protocol Implementation: 5

IDCRC Citation Statement

Please include the following citation in any publications resulting from direct or indirect IDCRC support:

"Supported by the Infectious Diseases Clinical Research Consortium through the National Institute for Allergy and Infectious Diseases of the National Institutes of Health, under award number UM1AI148684. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health."

Publications